Investigation of the roles of TGFβ1, CUG2, TGFBI genes, and thiol-disulfide balance on prostate cancer and metastasis

Abstract Objectives Transforming growth factor-beta (TGFβ1) is involved in tumorigenesis and metastasis. It provides this effect both by disrupting the thiol-disulfide balance through cancer-upregulated gene (CUG2) transforming factor beta-induced (TGFBI) genes signaling pathway. In study, roles of TGFβ1 related genes, as well balance, formation prostate cancer metastasis were investigated. Methods Tissue samples taken from 33 benign prostatic hyperplasia (BPH) 35 (PC) patients to determine Gleason score TGFβ1, CUG2, TGFBI expression levels measured RT-PCR. Serum specific antigen (PSA) patients, PSA density (PSAD) was calculated. Total thiol native measurements serum performed spectrophotometrically, disulfide Results with metastases, PSAD high, while total significantly lower (p<0.05). CUG2 higher metastases negatively correlated (p<0.001). Conclusions As a result our we determined that increase CUG 2 plays an important role balance.